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Ketamine is a medication mainly used for starting and maintaining anesthesia. It induces a trance-like state while providing pain relief, sedation, and memory loss. Other uses include for chronic pain and for sedation in intensive care. Heart function, breathing, and airway reflexes generally remain functional. Ketamine is a drug that serves multiple purposes, it affects multiple pathways in the brain. Interacting with the glutamate system in our brain, it blocks glutamate receptors. Glutamate plays a role in neuron communication, so hindering their reception will create the anesthetic effect in the brain. Similar to how naltrexone interacts with opiate receptors, low doses of ketamine may actually increase production of the neurotransmitter it inhibits.

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At lower doses, ketamine has shown potential to help with pain, depression, and other mental health issues. Upon taking ketamine, the effects can be felt immediately. This is opposed to other medications, such as Selective Serotonin Reuptake Inhibitors (SSRIs), that may be used to treat depression. While the SSRIs need time to build up in your brain, ketamine will begin to affect the neurotransmitter activity in your brain once administered. Today, SSRIs (drugs that increase serotonin levels) rank among the most prescribed psychiatric medicines. Serotonin is thought to increase the sense of well-being. SSRIs have had negative side effects, however, sometimes increasing the risk of suicide in some patients, diminishing libido in others, and often taking weeks to work. But the major problem with SSRIs and the other antidepressants is that, as a group, they fail to help about one-third of patients who try them.

This is why there’s so much excitement around ketamine. It offers relief to many patients who previously didn’t respond to anything. When it works, the drug acts within hours, not weeks, which makes it especially promising for patients at risk of suicide. And because it targets a different neurotransmitter system (not serotonin but glutamate) it’s giving scientists new insight into the biology of depression and other mental health disorders. See how ketamine can help with different disorders. ketamine treatment near me

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Ketamine for Depression:

Recent breakthroughs in ketamine research highlight the positive effects it has on people with depression. Particularly for people who have tried other anti-depressants and failed. Ketamine works differently within the brain compared to SSRIs that are commonly prescribed to treat depression. Ketamine, once administered, works very quickly. The antidepressant effect of ketamine is detectable 40 minutes after the dose is given. A 2014 study provides controlled evidence of “significant improvement in depressive symptoms within 24 hours after ketamine compared to placebo.” Intranasal ketamine showed minimal psychotomimetic or dissociative effects. With a proper ketamine implementation strategy, this drug can help the brain foster new neuron connections and provide long-term alleviation.ketamine treatment near me

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Ketamine for Chronic Pain:

Ketamine has also been shown to have positive effects on chronic pain syndromes. Though the exact process has not been mapped out, ketamine influences pain in a variety of ways. Primarily, ketamine acts as an N-methyl-D-aspartate (NMDA) receptor inhibitor. Neurogenic pain is greatly influenced by the NMDA-receptor system and, “antagonizing this system may be a useful way to obtain better pain control.” Ketamine also has anti-inflammatory effects as well as enhances the descending inhibition of pain. Studies have shown that infusion from 4-14 days can lead to long-term analgesic effects for up to 3 months. Some side effects include, “psychedelic symptoms (hallucinations, memory defects, panic attacks), nausea/vomiting, somnolence, cardiovascular stimulation and, in a minority of patients, hepatoxicity.” However, some studies have shown benzodiazepines are able to reduce the psychotropic side effects.

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Ketamine for Anxiety:

A recent study looked into the effectiveness of ketamine in treating social anxiety disorder. 18 adults who were diagnosed with DSM-5 social anxiety disorder were in a randomized, double-blind trial in which intravenous ketamine and a placebo were given to the participants. After two weeks, participants had a significant anxiety reduction when measured by the Liebowitz Social Anxiety Scale (LSAS). This gives us initial evidence that ketamine may be able to help patients with anxiety, especially if they have tried other medications and failed.ketamine treatment near me

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